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KMID : 1007520150240010265
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Food Science and Biotechnology
2015 Volume.24 No. 1 p.265 ~ p.271
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Polyphenolic Contents and the Effects of Methanol Extracts from Mango Varieties on Breast Cancer Cells
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Van Le Thu Hoang
Jean-Thomas Pierson
Merril Carmel Curry
Paul Nicholas Shaw
Ralf Georg Dietzgen
Michael John Gidley
Sarah Jane Roberts-Thomson
Gregory Raymond Monteith
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Abstract
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Bioactivities of peel and flesh extracts of 3 genetically diverse mango (Mangifera indica L.) varieties were studied. Nam Doc Mai peel extracts, containing the largest amounts of polyphenols, were associated with an effect on MCF-7 viable cell numbers with an IC50 (dose required for 50% inhibition of cell viability) of 56 μg/mL and significantly (p<0.01) induced cell death in MDA-MB- 231 cells, compared with other varieties. Hydrophilic fractions of Nam Doc Mai peel extracts had the highest bioactivity values against both MCF-7 and MDA-MB-231 cells. Soluble polyphenols were present in the largest amounts in most hydrophilic fractions. The Nam Doc Mai mango variety contains high levels of fruit peel bioactivity, which appears to be related to the nature of the polyphenol composition.
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KEYWORD
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mango, polyphenolic, breast cancer, viability
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